Rapid, Phase-free Detection of Long Identity-by-Descent Segments Enables Effective Relationship Classification
نویسندگان
چکیده
منابع مشابه
On Relationship Inference Using Gamete Identity by Descent Data
Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Po...
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To my parents, for their years of support and encouragement. ii ACKNOWLEDGMENTS This work would not have been possible without help and support of many people. I would to thank my advisor Dr. Xenofon Koutsoukos, whose guidance and advice was infinitely valuable in allowing me to complete this project. I would also like to thank Dr. Mitchell Wilkes for graciously agreeing to be the second reader...
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a problem of computer vision applications is to detect regions of interest under dif- ferent imaging conditions. the state-of-the-art maximally stable extremal regions (mser) detects affine covariant regions by applying all possible thresholds on the input image, and through three main steps including: 1) making a component tree of extremal regions’ evolution (enumeration), 2) obtaining region ...
Conflation of Short Identity-by-Descent Segments Bias Their Inferred Length Distribution
Identity-by-descent (IBD) is a fundamental concept in genetics with many applications. In a common definition, two haplotypes are said to share an IBD segment if that segment is inherited from a recent shared common ancestor without intervening recombination. Segments several cM long can be efficiently detected by a number of algorithms using high-density SNP array data from a population sample...
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Maize foundation parents (FPs) play no-alternative roles in hybrid breeding because they were widely used in the development of new lines and hybrids. The combination of different identity-by-descent (IBD) segments and genes could account for the formation patterns of different FPs, and knowledge of these IBD regions would provide an extensive foundation for the development of new candidate FP ...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2020
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2020.02.012